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Uric Acid Levels

About Hyperuricemia and it’s effect on Gout

Gout is an inflammatory response of urate crystals in the joints. These crystals form when there is an abnormally high level of uric acid in the body. Uric acid is naturally present in small amounts in the body. It’s an end product that results from the body’s normal process of catabolism. It also accumulates from processing of purines contained in some foods.

An elevated level of uric acid is considered hyperuricemia. Normally, uric acid is soluble in the blood and is eliminated by the kidneys. When more uric acid is produced than the kidneys can clear, the serum uric acid level increases to greater than 6.8 mg/dL, the limit of solubility.

Years of sustained hyperuricemia (often 20 years or more) can lead to storage of excess uric acid throughout the body. When the uric acid level is above 6.8 mg/dL, crystallization of the uric acid as sodium urate can occur. These crystals accumulate in the joints and can set the stage for painful attacks of gouty arthritis.

Once someone has hyperuricemia, any of the following can trigger a painful attack:

• Trauma
• Surgery
• Excessive consumption of purine-rich foods or alcohol

Lowering Uric Acid

Most experts agree that a uric acid level less than 6.0 mg/dL is necessary to prevent the consequences of hyperuricemia and goutty arthritis. It is recommended to monitor the serum uric acid level of patients with hyperuricemia and gout every six months.